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I was diagnosed with pleurisy yesterday - intense pain on inhalation/yawning/coughing etc - in fact anything that involved inflating the lungs felt like I was being stabbed in the side. Was prescribed Dicloflex (Diclofenac sodium in UK) in 3 x 50mg tablets a day. Didn't seem to make a lot of difference the first day, so I continued using Paracetamol codeine for pain relief. Today I've been a lot more comfortable - it seems like it took three doses to get started. I was even able to yawn earlier and I spent a little time sleeping lying down this morning - both of which would've been impossible yesterday.
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Little or no unchanged unconjugated drug is excreted.

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The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.

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In another nonlimiting embodiment, the invention includes a method of protecting a subject with osteoarthritis from UV exposure and alleviating the signs and symptoms of osteoarthritis in the subject comprising the steps of applying a therapeutically effective amount of a topical diclofenac in DMSO; waiting for the treated area to dry (the time of which can be dependent on individual skin characteristics, environmental conditions such as temperature and humidity, and surface area, often about 5-30 minutes, about 5-20 minutes, for example, and typically about 10 minutes or less for a topical diclofenac preparation, including a topical diclofenac solution as described in the Examples), applying sunscreen to the same area of treatment.

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In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, coadministration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.

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In another nonlimiting embodiment, such nonlimiting information provided to a user includes the information described in Example 11, or a summary thereof.

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FDA announces important changes and additional warnings for COX-2 selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs).

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In another nonlimiting embodiment, the user is provided with information consisting essentially of the Attachment.

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